An alternatively spliced isoform of B-Myb is a transcriptional inhibitor
نویسندگان
چکیده
منابع مشابه
An alternatively spliced isoform of transcriptional repressor ATF3 and its induction by stress stimuli.
Activating transcription factor 3 (ATF3) is a member of the ATF/CREB family of transcription factors and its expression is increased by various pathophysiological conditions and in several cancer cells. In this study, we describe two alternatively spliced ATF3DeltaZip mRNAs: ATF3DeltaZip2a and ATF3DeltaZip2b. Both variants encoded the same truncated protein of 135 amino acids, which lacked the ...
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Glycogen synthase kinase-3beta-dependent phosphorylation of cyclin D1 at a conserved COOH-terminal residue, Thr-286, promotes CRM1-dependent cyclin D1 nuclear export at the G(1)-S boundary. Mutations that perturb the phosphorylation of cyclin D1 at Thr-286 contribute to cell transformation, although to date, no such mutations have been found in human cancers. Cyclin D1 (CCND1) undergoes alterna...
متن کاملA sugarcane R2R3-MYB transcription factor gene is alternatively spliced during drought stress
MYB transcription factors of the R2R3-MYB family have been shown to play important roles in many plant processes. A sugarcane R2R3-MYB gene (ScMYB2) and its two alternative forms of transcript (ScMYB2S1 and ScMYB2S2) were identified in this study. The deduced protein of ScMYB2S1 is a typical plant R2R3-MYB protein, while ScMYB2S2 encodes a truncated protein. Real-time qPCR analysis revealed tha...
متن کاملELAV, a Drosophila neuron-specific protein, mediates the generation of an alternatively spliced neural protein isoform
BACKGROUND Tissue-specific alternative pre-mRNA splicing is a widely used mechanism for gene regulation and the generation of different protein isoforms, but relatively little is known about the factors and mechanisms that mediate this process. Tissue-specific RNA-binding proteins could mediate alternative pre-mRNA splicing. In Drosophila melanogaster, the RNA-binding protein encoded by the ela...
متن کاملA role for an alternatively spliced Id3 isoform in vascular lesions?
Alterations in proliferation, migration, and function of vascular smooth muscle cells (SMCs) are important in the formation of atherosclerotic and restenotic lesions.1 Although of tremendous clinical importance, the precise molecular mechanisms controlling the proliferation and differentiation of SMCs are not completely understood. Regulation of growth and differentiation in skeletal and cardia...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2000
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1203937